Novel stable glass formulations give permanent stability to monovalent and multivalent vaccines alike. Glass microspheres containing stabilised vaccines are suspended in inert, rapidly metabolised liquids as vehicles for injection.
The key to Cambridge Biostability's technology is not a new process. Rather, it is a novel twist on a process invented by nature itself to protect anhydrobiotic organisms like the Resurrection Plant or the Water Bear. These amazing organisms can dry out completely and appear to be dead. In fact they have been kept in a museum cupboard for over 100 years and yet they unfold and come back to life rapidly when they are rehydrated. The video above shows how an apparently dead Resurrection Plant comes back to life when placed in contact with water. The whole process, filmed using time-lapse photography, took just four hours. This ability is shared by simple micro-organisms such as baker’s yeast and by some simple plants and microscopic animals.
Such organisms survive in drought conditions by producing high concentrations of glass-forming sugars in their tissues. These solidify as a glass as the organism dehydrates, preserving the cells and tissues in a state of suspended animation. When water is once again available the solid sugar glass dissolves away, bringing the organism back to life.
Cambridge Biostability uses a modern version of this process to stabilise vaccines. We have identified and developed new and improved glass forming materials and combined them resulting in mixed glasses with ideal properties for stabilising vaccines and drugs.
To find out more about how this revolutionary new process works click here
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